Abstract
The origin and growth of the chemistry of 1,4-benzodioxins, 1,4-benzoxazines and their
2,3-dihydro derivatives are briefly described. This class of compounds has attracted
special attention due to their natural occurrence and important biological activities.
The structural scaffolds of these heterocycles serve as building blocks in various
useful syntheses. The introduction of palladium-catalyzed reactions has added a new
dimension to this field by making the synthesis more convenient and general. The purpose
of this account is to facilitate and revitalize interest in this field within the
synthetic community.
1 Introduction
2 Naturally Occurring Derivatives
2.1 2,3-Dihydro-1,4-benzodioxin Derivatives
2.2 2,3-Dihydro-1,4-benzoxazine Derivatives
3 Medicinal Importance
3.1 1,4-Benzodioxins and their 2,3-Dihydro Derivatives
3.2 1,4-Benzoxazines and their 2,3-Dihydro Derivatives
4 Synthetic Methods
4.1 1,4-Benzodioxins
4.2 2,3-Dihydro-1,4-benzodioxins
4.3 1,4-Benzoxazines
4.4 2,3-Dihydro-1,4-benzoxazines
4.5 1,4-Benzoxazin-3-ones and Derivatives
4.6 2,3-Dihydro-2-(or 3)-aryl(alkyl)idene-1,4-benzoxazins
5 Synthetic Applications
5.1 1,4-Benzodioxanes
5.2 1,4-Benzoxazines
6. Conclusions
1,4-benzodioxin - 1,4-benzoxazine - biological significance - natural products - syntheses
- palladium catalyst - synthetic intermediates
