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Dtsch Med Wochenschr 2004; 129(42): 2255-2260
DOI: 10.1055/s-2004-831875
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Dermatologie / Onkologie
© Georg Thieme Verlag Stuttgart · New York

Basalzellkarzinome - Ein Überblick

Basal cell carcinoma - An overviewJ. Dissemond1 , S. Grabbe1
  • 1Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen
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Publication History

eingereicht: 10.5.2004

akzeptiert: 22.7.2004

Publication Date:
14 October 2004 (online)

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Das Basalzellkarzinom ist nicht nur der häufigste nicht benigne kutane Tumor, sondern auch die weltweit am häufigsten vorkommende Neoplasie der weißen Bevölkerung und somit auch von großer interdisziplinärer Relevanz [46]. Obwohl bereits 1827 die Erstbeschreibung durch Jakob erfolgte, ist bis heute die Nomenklatur nicht einheitlich (Tab. [1]). Im deutschsprachigen Raum ist weitestgehend der von Nékám 1901 vorgeschlagene Begriff Basaliom durch den Terminus Basalzellkarzinom ersetzt worden [27]. Basalzellkarzinome zeichnen sich durch ein proliferatives lokal destruierendes Wachstum aus. Die Tendenz zur Metastasierung ist jedoch gering ausgeprägt, so dass Basalzellkarzinome als semimaligne fibroepitheliale Tumore mit Adnexcharakter bezeichnet werden [6].

Tab. 1 Synonyme Bezeichnungen des Basalzellkarzinoms. Basaliom Basalzellepitheliom Basalzellkarzinom Epithelioma basocellulare

Literatur

  • 1 Alcalay J, Freeman S E, Goldberg L H, Kripke M L, Wolf J E. Decreased excision repair of pyrimidine dimers induced in the skin of basal cell carcinoma patients by simulated solar radiation.  J Invest Dermatol. 1990;  94 502
    Search in Google Scholar
  • 2 Asada M, Korge B, Almeida H. et al . Solid basal cell epithelioma possibly originates from the lower part of the outer root sheath.  Zbl Haut. 1991;  158 2320
    Search in Google Scholar
  • 3 Bath F J, Bong J, Perkins W, Williams H C. Interventions for basal cell carcinoma of the skin.  Cochrane Database Syst Rev. 2003;  2 CD003412
    Search in Google Scholar
  • 4 Blum A, Metzler G, Hofmann-Wellenhof R, Soyer H P, Garbe C, Bauer J. Correlation between dermoscopy and histopathology in pigmented and non-pigmented skin tumours.  Hautarzt. 2003;  54 279-291
    Search in Google Scholar
  • 5 Bavinck J N, Bastiaens M T, Marugg M E. et al . Further evidence for an association of HLA-DR7 with basal cell carcinoma on the tropical island of Saba.  Arch Dermatol. 2000;  136 1019-1022
    Search in Google Scholar
  • 6 Breuninger H, Garbe K. Basalazellkarzinom.  Hautarzt. 1998;  10 S15-19
    Search in Google Scholar
  • 7 Calista D. Topical 1 % cidofovir for the treatment of basal cell carcinoma.  Eur J Dermatol. 2002;  12 562-564
    Search in Google Scholar
  • 8 Czarnecki D, Lewis A, Nicholson I, Tait B. Multiple basal cell carcinomas and HLA frequencies in southern Australia.  J Am Acad Dermatol. 1991;  24 559-561
    Search in Google Scholar
  • 9 Danopoulos E D, Danopoulou I E. Regression of liver cancer with oral urea.  Lancet. 1974;  1 132
    Search in Google Scholar
  • 10 D’Errico M, Calcagnile A S, Corona R. et al . p53 mutations and chromosome instability in basal cell carcinomas developed at an early or late age.  Cancer Res. 1997;  57 747-752
    Search in Google Scholar
  • 11 Euvrard S, Kanitakis J, Claudy A. Skin cancers after organ transplantation.  N Engl J Med. 2003;  348 1681-1691
    Search in Google Scholar
  • 12 George R, Weightman W, Russ G R, Bannister K M, Mathew T H. Acitretin for chemoprevention of non-melanoma skin cancers in renal transplant recipients.  Australas J Dermatol. 2002;  43 269-273
    Search in Google Scholar
  • 13 Giuffrida T J, Jimenez G, Nouri K. Histologic cure of basal cell carcinoma treated with cryosurgery.  J Am Acad Dermatol. 2003;  49 483-486
    Search in Google Scholar
  • 14 Greinert R, Volkmer B, Wende A, Voss S, Breitbart E W. Prävention von Hautkrebs. Notwendigkeit, Durchführung und Erfolg.  Hautarzt. 2003;  54 1152-1163
    Search in Google Scholar
  • 15 Kanitakis J, Alhaj-Ibrahim L, Euvrard S, Claudy A. Basal cell carcinomas developing in solid organ transplant recipients: clinicopathologic study of 176 cases.  Arch Dermatol. 2003;  139 1133-1137
    Search in Google Scholar
  • 16 Katiyar S K, Ahmad N, Mukhtar H. Green tea and skin.  Arch Dermatol. 2000;  136 989-994
    Search in Google Scholar
  • 17 Kim K H, Yavel R M, Gross V L, Brody N. Intralesional Interferon alpha-2b in the Treatment of Basal Cell Carcinoma and Squamous Cell Carcinoma: Revisited.  Dermatol Surg. 2004;  30 116-120
    Search in Google Scholar
  • 18 Kopf A. Computer analysis of 3531 basalcell carcinomas of the skin.  J Derm. 1979;  6 267-281
    Search in Google Scholar
  • 19 Kowalzick L, Rogozinski T, Wimheuer R. et al . Intralesional recombinant interferon beta-1a in the treatment of basal cell carcinoma: results of an open-label multicentre study.  Eur J Dermatol. 2002;  12 558-561
    Search in Google Scholar
  • 20 Kumar P, Watson S, Brain A N. et al . Incomplete excision of basal cell carcinoma: a prospective multicentre audit.  Br J Plast Surg. 2002;  55 616-622
    Search in Google Scholar
  • 21 Lear J T, Smith A G. Basal cell carcinoma.  Postgrad Med J. 1997;  73 538-542
    Search in Google Scholar
  • 22 Levi F, La Vecchia C, Te V C, Randimbison L, Erler G. Incidence of invasive cancers following basal cell skin cancer.  Am J Epidemiol. 1998;  147 722-726
    Search in Google Scholar
  • 23 Marmur E S, Schmults C D, Goldberg D J. A review of laser and photodynamic therapy for the treatment of nonmelanoma skin cancer.  Dermatol Surg. 2004;  30 264-271
    Search in Google Scholar
  • 24 Miller S J. Biology of basal cell carcinoma (Part I).  J Am Acad Dermatol. 1991;  24 1-13
    Search in Google Scholar
  • 25 Moore J V, Allan E. Pulsed ultrasound measurements of depth and regression of basal cell carcinomas after photodynamic therapy: relationship to probability of 1-year local control.  Br J Dermatol. 2003;  149 1035-1040
    Search in Google Scholar
  • 26 Nagore E, Grau C, Molinero J, Fortea J M. Positive margins in basal cell carcinoma: relationship to clinical features and recurrence risk. A retrospective study of 248 patients.  J Eur Acad Dermatol Venereol. 2003;  17 167-170
    Search in Google Scholar
  • 27 Nékám L. Basalioma adenoides cysticum esete.  Orvosi Hetilap. 1901;  39 1-10
    Search in Google Scholar
  • 28 Nickoloff B J, Qin J Z, Chaturvedi V, Bacon P, Panella J, Denning M F. Life and death signaling pathways contributing to skin cancer.  J Invest Dermatol Symp Proc. 2002;  7 27-35
    Search in Google Scholar
  • 29 Nijsten T E, Stern R S. The increased risk of skin cancer is persistent after discontinuation of psoralen+ultraviolet A: a cohort study.  J Invest Dermatol. 2003;  121 252-258
    Search in Google Scholar
  • 30 Peterson S R, Goldberg L H. New and emerging treatments for nonmelanomas and actinic keratoses.  J Drugs Dermatol. 2003;  2 429-432
    Search in Google Scholar
  • 31 Pfeiffer P, Hansen O, Rose C. Systemic cytotoxic therapy of basal cell carcinoma. A review of the literature.  Eur J Cancer. 1990;  26 73-77
    Search in Google Scholar
  • 32 Pfister R. Antibiotische Behandlung maligner epthelialer Tumoren.  Fortschr Med. 1977;  12 784-787
    Search in Google Scholar
  • 33 Reyman F. Treatment of basal cell carcinoma of the skin with 5-Fluorouracil ointment. A 10-year follow-up study.  Dermatologica. 1979;  158 368-372
    Search in Google Scholar
  • 34 Rhodes L E, de Rie M, Enstrom Y. et al . Photodynamic therapy using topical methyl aminolevulinate vs surgery for nodular basal cell carcinoma: results of a multicenter randomized prospective trial.  Arch Dermatol. 2004;  140 17-23
    Search in Google Scholar
  • 35 Robins W. Chemosurgery: My 15 years of experimence.  J Dermatol Surg Oncol. 1981;  9 79-789
    Search in Google Scholar
  • 36 Rozylo-Kalinowska I, Rozylo T K. Odontogenic keratocyst in Gorlin-Goltz syndrome.  Ann Univ Mariae Curie Sklodowska. 2002;  57 79-85
    Search in Google Scholar
  • 37 Safai B, Good R A. Basal cell carcinoma with metastasis. Review of the literature.  Arch Pathol Lab Med. 1977;  101 327-331
    Search in Google Scholar
  • 38 Schon M, Bong A B, Drewniok C. et al . Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod.  J Natl Cancer Inst. 2003;  95 1138-1149
    Search in Google Scholar
  • 39 Seegenschmiedt M H, Oberste-Beulmann S, Lang E, Lang B, Guntrum F, Olschewski T. Strahlentherapie des Basalzellkarzinoms.  Strahlenther Onkol. 2001;  177 240-246
    Search in Google Scholar
  • 40 Smyth I, Narang M A, Evans T. et al . Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32.  Hum Mol Genet. 1999;  8 291-297
    Search in Google Scholar
  • 41 Spates S T, Mellette J R, Fitzpatrick J. Metastatic basal cell carcinoma.  Dermatol Surg. 2003;  29 650-652
    Search in Google Scholar
  • 42 Szeimies R M, Landthaler M. Photodynamic therapy and fluorescence diagnosis of skin cancers.  Recent Results Cancer Res. 2002;  160 240-245
    Search in Google Scholar
  • 43 Tangrea J A, Edwards B K, Taylor P R. et al . Long-term therapy with low-dose isotretinoin for prevention of basal cell carcinoma: a multicenter clinical trial. Isotretinoin-Basal Cell Carcinoma Study Group.  J Natl Cancer Inst. 1992;  84 328-332
    Search in Google Scholar
  • 44 Thissen M R, Neumann M H, Schouten L J. A systematic review of treatment modalities for primary basal cell carcinomas.  Arch Dermatol. 1999;  135 1177-1183
    Search in Google Scholar
  • 45 Thomas D J, King A R, Peat B G. Excision margins for nonmelanotic skin cancer.  Plast Reconstr Surg. 2003;  2 57-63
    Search in Google Scholar
  • 46 Tran H, Chen K, Shumack S. Epidemiology and aetiology of basal cell carcinoma.  Br J Dermatol. 2003;  149 50-52
    Search in Google Scholar
  • 47 Van Scott E G, Reinertson R P. The modulating influence of stromal environment on epithelial cells studied in human autotransplants.  J Invest Dermatol. 1961;  39 183-189
    Search in Google Scholar
  • 48 von Domarus H, Stevens P J. Metastatic basal cell carcinoma. Report of five cases and review of 170 cases in the literature.  J Am Acad Dermatol. 1984;  10 1043-1060
    Search in Google Scholar
  • 49 Wallberg P, Skog E. The incidence of basal cell carcinoma in an area of Stockholm County during the period 1971 - 1980.  Acta Derm Venereol. 1991;  71 134-137
    Search in Google Scholar
  • 50 Zeitouni N C, Oseroff A R, Shieh S. Photodynamic therapy for nonmelanoma skin cancers. Current review and update.  Mol Immunol. 2003;  39 1133-1136
    Search in Google Scholar

Dr. med. Joachim Dissemond

Universitätsklinikum Essen, Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie

Hufelandstraße 55

45122 Essen

Phone: 0201/7233894

Fax: 0201/7235935

Email: joachimdissemond@hotmail.com