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Synthesis 2004(13): 2222-2225  
DOI: 10.1055/s-2004-829180
SPECIALTOPIC
© Georg Thieme Verlag Stuttgart · New York

1-Aza-2-siloxybutadiene: Structure and Synthetic Application as a Piperidinone Synthon

Kiyosei Takasu*, Naoko Nishida, Masataka Ihara*
Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan
Fax: +81(22)2176879; e-Mail: mihara@mail.pharm.tohoku.ac.jp;
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Publication History

Received 21 May 2004
Publication Date:
30 July 2004 (online)

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Abstract

Synthesis of 1-aza-2-siloxydienes and their structural analysis by multinuclear NMR are described. Moreover, the cycloaddition reaction of the isolated 1-aza-2-siloxydienes with dienophiles to synthesize piperidin-2-ones was explored.

Key words

silicon - amides - piperidines - cycloadditions - tandem reactions

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