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Dtsch Med Wochenschr 2003; 128(23): 1301-1306
DOI: 10.1055/s-2003-39798
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© Georg Thieme Verlag Stuttgart · New York

Porcine endogene Retroviren (PERVs) und Xenotransplantation

Ein Risiko für Rezipient und Gesellschaft?Porcine endogenous retroviruses (PERVs) and xenotransplantationA risk for the recipient and for society?V. Specke1 , J. Denner1
  • 1Robert Koch-Institut, Berlin
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Publication History

eingereicht: 2.12.2002

akzeptiert: 27.2.2003

Publication Date:
05 June 2003 (online)

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Die Xenotransplantation, d. h. die Transplantation von tierischen Zellen, Geweben und Organen auf den Menschen, stellt eine vielversprechende Möglichkeit dar, den Mangel an verfügbaren menschlichen Transplantaten zu überbrücken. Aus verschiedenen Gründen werden zur Zeit Schweine als potenzielle Spender von Xenotransplantaten favorisiert. Jedoch ist mit der Verwendung porciner Xenotransplantate das Risiko einer Übertragung von Mikroorganismen auf den humanen Rezipienten verbunden. Dabei geht das größte Risiko von den porcinen endogenen Retroviren (PERVs) aus, die in vielfachen Kopien im Genom aller Schweinerassen integriert sind und die humane Zellen in vitro infizieren. Die PERVs sind mit Retroviren verwand, von denen die meisten Tumore und Immundefizienzen im infizierten Wirt hervorrufen können. Es muss deshalb geprüft werden, ob die Transplantation porciner Organe auf den Menschen eine Übertragung dieser Viren mit sich bringt und damit ein Risiko für den Rezipienten und die Gesellschaft darstellen könnte.

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Dr. Joachim Denner

Robert Koch-Institut

Nordufer 20

13353 Berlin

Phone: +49/030/45472800

Fax: +49/030/45472801

Email: DennerJ@rki.de