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Dtsch Med Wochenschr 2002; 127(9): 451-456
DOI: 10.1055/s-2002-20427
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© Georg Thieme Verlag Stuttgart · New York

Der selektive Tyrosinkinase-Inhibitor Imatinib (STI571) bei hämatologischen und onkologischen Erkrankungen

Selective tyrosinekinase inhibitor imatinib (STI571) in haematological and oncological diseaseA. Hochhaus
  • III. Medizinische Universitätsklinik (Direktor: Prof. Dr. R. Hehlmann), Fakultät für Klinische Medizin Mannheim der Universität Heidelberg
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Publication History

Manuskript-Eingang: 27. Dezember 2001

Annahme nach Revision: 06. Februar 2002

Publication Date:
28 February 2002 (online)

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Proteinkinasen sind eine große Familie homologer Proteine, die aus zwei Subfamilien, den Serin-Threonin-Kinasen und den Tyrosinkinasen, besteht. Sie sind Teil der Signaltransduktionswege und spielen eine zentrale Rolle in verschiedenen biologischen Prozessen, wie Zellwachstum, Stoffwechsel, Differenzierung und Apoptose. Tyrosinkinasen binden ATP und übertragen Phosphatgruppen von ATP auf Tyrosinreste verschiedener Substrate. Imatinib (Glivec®, früher STI571 oder CGP57148B) ist ein selektiver Inhibitor der strukturell ähnlichen Tyrosinkinasen ABL, PDGF-R und c-kit ([Abb. 1] und [2] ).

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Korrespondenz

Priv.-Doz. Dr. med. Andreas Hochhaus

III. Medizinische Universitätsklinik, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg

Wiesbadener Straße 7-11

68305 Mannheim

Phone: 0621/3832854

Fax: 0621/3833833

Email: hochhaus@uni-hd.de