Palladium-Tetraphosphine Complex: An Efficient Catalyst for Allylic Substitution and Suzuki Cross-Coupling

Abstract

A new tetraphosphine, the cis-cis-cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane (Tedicyp) has been synthesized and used in palladium-catalyzed reactions. This tetraphosphine in combination with [Pd(C₃H₅)Cl]₂ affords a very efficient catalyst for coupling reactions. Turnover numbers of 980 000 for allylic amination, 9 800 000 for allylic alkylation and 97 000 000 for Suzuki cross-coupling can be obtained in the presence of this catalyst.

palladium - phosphines - catalysis - alkylation - amination

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