Synlett
DOI: 10.1055/s-0043-1775481
letter
Emerging Trends in Organic Chemistry: A Focus on India

Silver(I) Oxide Catalyzed C/S–H Trifluoromethylation of Arenes and Heteroarenes with Sodium Trifluoromethanesulfinate

Km Sadhana
,
Sandeep Kumawat
,
Kallakuri Leela Manikya Naga Siva Jyothi
,

K.S. and K.L.M.N.S.J. are grateful to CSIR-JRF for fellowships. S.K. is grateful for a UGC-JRF fellowship.


Abstract

We present a general and scalable approach for the C(sp2)–H or S–H trifluoromethylation of arenes and heteroarenes. This method employs bench-stable CF3SO2Na as the CF3 source, with Ag2O serving as the catalyst and K2S2O8 as the oxidant. Notably, the protocol features broad functional-group compatibility, mild conditions, and high regioselectivity. Furthermore, it is applicable to biologically relevant molecules such as caffeine, pentoxifylline, ganciclovir triacetate, and mercaptopurine.

Supporting Information



Publication History

Received: 28 February 2025

Accepted after revision: 07 April 2025

Article published online:
09 May 2025

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