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Synlett 2025; 36(05): 474-479
DOI: 10.1055/s-0043-1775388
DOI: 10.1055/s-0043-1775388
letter
Direct Synthesis of N-Substituted Phosphinecarboxamides from [TBA][P(SiCl3)2] and Isonitriles
Autoren
We thank the National Natural Science Foundation of China (Nos. 22061038, 22067018 and 21562036) for financial support.
Abstract
In this investigation, N-substituted phosphinecarboxamides were produced through the reaction of [TBA][P(SiCl3)2] with isonitriles. This method capitalizes on the flexibility of isonitriles as a source of both nitrogen and carbonyl groups, offering a novel route to the generation of PH2-type compounds. This approach is characterized by rapid reaction times, simple procedural requirements, compatibility with a diverse array of substrates, and the conversion of [TBA][P(SiCl3)2] into organic phosphorus compounds. Additionally, we systematically studied the reaction mechanism of isonitrile with [TBA][P(SiCl3)2] through controlled experiments and density functional theory (DFT) calculations.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1775388.
- Supporting Information (PDF) (opens in new window)
Publikationsverlauf
Eingereicht: 11. Juni 2024
Angenommen nach Revision: 15. Juli 2024
Artikel online veröffentlicht:
29. August 2024
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