Abstract
The Isay reaction was used to synthesize novel disubstituted pteridine derivatives.
The pteridine scaffold was synthesized by reacting a mercaptopyrimidine derivative
with a substituted diketone, followed by a reaction with a substituted phenylurea
derivative. Standard physicochemical and spectroscopic techniques, such as FTIR, mass
spectrometry, 1H NMR, D2O exchange, and HPLC confirmed the structures and purities of the synthesized compounds.
Various key substituents on the phenylurea and on the pteridine scaffold were incorporated
to explore their effects on the chemical and biological properties of the products.
Molecular-docking studies against proteins PI3K (PDB ID: 4L23) and mTOR (PDB ID: 4JT6),
showed promising interactions that supported the potential biological activity of
the pteridine derivatives. These findings provide a strong basis for further optimization
and biological evaluation, particularly in the development of novel anticancer agents.
Key words
pteridines - mercapto pyrimidines - Isay reaction - molecular docking - medicinal
chemistry - anticancer agents
