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DOI: 10.1055/s-0043-1773531
Expanding the Horizon of Pteridine Chemistry: Optimized Synthesis by the Isay Reaction, and Molecular-Docking Studies
S.K.S. is grateful to Nirma University, Ahmedabad, India for providing financial support and facilities to carry out the work.

Abstract
The Isay reaction was used to synthesize novel disubstituted pteridine derivatives. The pteridine scaffold was synthesized by reacting a mercaptopyrimidine derivative with a substituted diketone, followed by a reaction with a substituted phenylurea derivative. Standard physicochemical and spectroscopic techniques, such as FTIR, mass spectrometry, 1H NMR, D2O exchange, and HPLC confirmed the structures and purities of the synthesized compounds. Various key substituents on the phenylurea and on the pteridine scaffold were incorporated to explore their effects on the chemical and biological properties of the products. Molecular-docking studies against proteins PI3K (PDB ID: 4L23) and mTOR (PDB ID: 4JT6), showed promising interactions that supported the potential biological activity of the pteridine derivatives. These findings provide a strong basis for further optimization and biological evaluation, particularly in the development of novel anticancer agents.
Key words
pteridines - mercapto pyrimidines - Isay reaction - molecular docking - medicinal chemistry - anticancer agentsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1773531.
- Supporting Information
Publication History
Received: 25 December 2024
Accepted after revision: 21 February 2025
Article published online:
07 April 2025
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