Abstract
Stereospecific approaches allow the introduction of a stereogenic center into complex
organic molecules using optically active reagents. Among these, the Pd-catalyzed stereospecific
cross-coupling of chiral alkylboron compounds stands out as a highly effective tool
for organic synthesis. In parallel with advances in the development of borylation
technology, the strategy has recently witnessed a growth in its applicability. This
account aims to review the progress on Pd-catalyzed stereospecific B-alkyl Suzuki–Miyaura cross-coupling, tracing its evolution from early breakthroughs
to the most recent advances.
1 Introduction
2 Cross-Coupling of 1° Alkylboron Compounds
3 Cross-Coupling of Benzylboron Compounds
4 Cross-Coupling of Allyl- and Propargylboron Compounds
5 Cross-Coupling of Other Types of Activated 2° Alkylboron Compounds
6 Cross-Coupling of Unactivated 2° Alkylboron Compounds
7 Conclusion and Outlook
Key words
stereospecific strategy - cross-coupling - palladium catalysis - alkylboron
