Dtsch Med Wochenschr 2016; 141(11): 752-756
DOI: 10.1055/s-0042-103979
Klinischer Fortschritt
Angiologie
© Georg Thieme Verlag KG Stuttgart · New York

Das akute Aortensyndrom

Acute aortic syndrome
Christoph A. Nienaber
1   Imperial College and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre in London, UK
› Author Affiliations
Further Information

Publication History

Publication Date:
02 June 2016 (online)

Zusammenfassung

Das akute Aortensyndrom ist der neue Oberbegriff fuer akute Erkrankungen der Aortenwand und umfasst sowohl Dissektion, intramurale Einblutung und Ulkusformation, als auch Traumatisierung der Gefaesswand mit einer jaehrlichen Inzidenz bis zu 35/100.000 im Alterssegment zwischen 65 und 75 Jahren. Histopathologisch nachweisbare Schaeden und eine genetische Disposition sind entscheidend fuer die Entstehung des Aortensyndroms, waehrend die anatomische Lokalisaton massgeblich ist fuer die Therapie mit chirurgischen Massnahmen im proximalen Abschnitt der Aorta und endovaskulaer-interventionellen Verfahren fuer den Bogen und die descendierende Aorta; in allen Faellen von Wanddissektion (sowohl im proximalen als auch distalen Segment) ist die Rekonstruktion der dissezierten Aorta Voraussetzung fuer eine langfristig verbesserte Prognose.

Abstract

Acute aortic syndrome is the common denominator for acute events to the aortic wall and encompasses dissection of the aorta, intramural hematoma, formation of aortic ulcers and trauma to the aorta with an annual incidence of up to 35 cases/100.000 between 65 and 75 years of age. Both, inflammation and/or microtrauma at the level of the aortic media layer, and a genetic disposition are promoting elements of AAS, while the extent and anatomic involvement of the ascending aorta call for either surgical resection/repair in the proximal part of the aorta, or an endovascular solution for pathologies in the distal aorta; in all cases of dissection (regardless of location) reconstruction/realignment has been proven to portend better long-term outcomes (in addition to medical management of blood pressure).

 
  • Literatur

  • 1 Olsson C, Thelin S, Ståhle E, Granath F. Thoracic aortic aneurysm and dissection: increasing prevalence and improved outcomes reported in a nationwide population-based study of more than 14, 000 cases from 1987 to 2002. Circulation 2006; 114: 2611-2618
  • 2 Acosta S, Ogren M, Bengtsson H et al. Increasing Incidence of ruptured abdominal aortic aneurysm: a population-based study. J Vasc Surg 2006; 44: 237-243
  • 3 Clouse WD, Hallett JW, Schaff HV et al. Acute aortic dissection; population-based incidence compared with degenerative aortic aneurysm rupture. Mayo Clin Proc 2004; 79: 176-180
  • 4 Office for National Statistics. National Population Projections. National population projections by age and sex for the UK and constituent countries. http:/www.statistics.gov.uk/hub/population/index.html
  • 5 Meszaros I, Morocz J, Szlavi J et al. Epidermiology and clinicopathology of aortic dissection. Chest 2000; 117: 1271-1278
  • 6 Howard DP, Banerjee A, Fairhead JF et al. Population-based study of incidence and outcome of acute aortic dissection and premorbid risk factor control; 10-year results from Oxford Vascular Study. Circulation 2013; 127: 2031-2037
  • 7 Roberts CS, Roberts WC. Aortic dissection with the entrance tear in the descending thoracic aorta. Analysis of 40 necropsy patients. Ann Surg 1991; 213: 356-368
  • 8 Sakalihazan N, Nienaber CA, Hustinx R et al. Tissue Inflammation (by PET imaging) and serologic Activity in the Evolution of Chronic Aortic Dissection. Eur Heart J 2014; (In press).
  • 9 Hiratzka LF, Bakris GL, Beckman JA et al. 2010 ACCF / AHA / AATS / ACR / ASA / SCA / SCAI / SIR / STS / SVM guidelines for the diagnosis and management of patients with thoracic aortic disease: executive summary. Catheter Cardiovasc Interv 2010; 76: E43-86
  • 10 Booher AM, Isselbacher EM, Nienaber CA et al. The IRAD classification system for characterizing survival after aortic dissection. Am J Med 2013; 126: 730.e19-24
  • 11 Schünke M, Schulte E, Schumacher E. Prometheus. LernAtlas der Anatomie. Innere Organe. 2. Aufl. Stuttgart: Thieme; 2009
  • 12 Dake MD, Thompson M, van Sambeek M et al. DISSECT: a new mnemonic-based approach to the categorization of aortic dissection. Eur J Endovasc Surg 2013; 46: 175-190
  • 13 Rogers IS, Banerji D, Siegel EL et al. Usefulness of comprehensive cardiothoracic computed tomography in the evaluation of acute undifferentiated chest discomfort in the emergency department (CAPTURE). Am J Cardiol 2011; 107: 643-650
  • 14 Suzuki T, Distante A, Zizza A et al. Diagnosis of acute aortic dissection by D-dimer: The International Registruy of Acute Aortic Dissection substudy on biomarkers (IRAD-Bio) experience. Circulation 2009; 70: 1598-1601
  • 15 Erbel R, Aboyans V, Boileau C et al. ESC Committee for Practical Guidelines. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Documents covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. Eur Heart J 2014; 35: 2873-2926
  • 16 Nienaber CA, Clough RE. Management of acute aortic dissection. Lancet 2015; 385: 800-811
  • 17 Clough RE, Nienaber CA. Management of acute aortic syndrome. Nat Rev Cardiol 2015; 12: 103-114