Herein, we report the synthesis of analogues of amino acids with a monofluorovinyl
moiety. Interestingly, we have found that cyclization of the obtained products proceeds
easily in all cases. The cyclization process has not previously been observed at this
reaction stage, and such fluorinated lactams derived from phenylalanine, valine, alanine
have not been described before.
Key words
amino acids - monofluorovinyl - cyclization - peptidomimetics - fluorinated lactam