Recent Progress in Amination Enabled by Transition-Metal-Free C(sp2)–O/C(sp2)–S Bond Cleavage Strategy

Shen-Huan Li; Cheng-Yu Long; Xin-Ge Yang; Xue-Qiang Wang

doi:10.1055/s-0040-1720382

Synthesis, Table of Contents

Synthesis 2021; 53(20): 3716-3724
DOI: 10.1055/s-0040-1720382

short review

Recent Progress in Amination Enabled by Transition-Metal-Free C(sp²)–O/C(sp²)–S Bond Cleavage Strategy

Shen-Huan Li

^aMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha, Hunan 410082, P. R. of China

,

Cheng-Yu Long

^aMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha, Hunan 410082, P. R. of China

,

Xin-Ge Yang∗

^bCollege of Chemistry and Chemical Engineering, Linyi University, Linyi, Shangdong, 276000, P. R. of China

,

Xue-Qiang Wang ∗

^aMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha, Hunan 410082, P. R. of China

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Abstract

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Abstract

Recently, intense efforts have been dedicated to the development of novel synthetic strategies to access aromatic amines due to their importance in the pharmaceuticals, agrochemicals, materials, and natural product areas. Although numerous transition-metal-catalyzed C–N formation strategies have been described for the preparation of aromatic amines in the past few decades, complementary methods under transition-metal-free conditions are still required. We present the recent advances in the exploration of innovative amination approaches via C(sp²)–O/C(sp²)–S bond cleavage in this review.

1 Introduction

2 Stoichiometric Base-Promoted Amination

3 Base-Catalyzed Amination

4 Photoredox-Catalyzed Amination

5 Acid-Promoted Amination

6 Conclusion and Perspectives

Key words

amination - arylamines - transition-metal-free - base-promoted - acid-catalyzed - photoredox-catalyzed

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References

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