Biocatalytic One-Carbon Transfer – A Review

In memory of Dr. Arren Bar-Even

Abstract

This review provides an overview of different C₁ building blocks as substrates of enzymes, or part of their cofactors, and the resulting­ functionalized products. There is an emphasis on the broad range of possibilities of biocatalytic one-carbon extensions with C₁ sources of different oxidation states. The identification of uncommon biosynthetic strategies, many of which might serve as templates for synthetic or biotechnological applications, towards one-carbon extensions is supported by recent genomic and metabolomic progress and hence we refer principally to literature spanning from 2014 to 2020.

1 Introduction

2 Methane, Methanol, and Methylamine

3 Glycine

4 Nitromethane

5 SAM and SAM Ylide

6 Other C₁ Building Blocks

7 Formaldehyde and Glyoxylate as Formaldehyde Equivalents

8 Cyanide

9 Formic Acid

10 Formyl-CoA and Oxalyl-CoA

11 Carbon Monoxide

12 Carbon Dioxide

13 Conclusions

Key words

biosynthesis - methyl transfer - enzyme cascades - enzymes - C₁ building blocks

Publication History

Received: 11 September 2021

Accepted after revision: 09 December 2021

Article published online:
08 August 2022

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