Synthesis of Allene-Containing Apocarotenoids by Cross-Coupling Strategy

Abstract

The stereocontrolled total synthesis of the allene and carbonyl conjugated apocarotenoids, paracentrone and 19-hexanoyloxyparacentrone 3-acetate, was achieved by sequential cross-coupling reactions using boronic acid ester and iodine- or tin-substituted C5 dienes, which were the building blocks for the elongation of the conjugated polyene systems at both terminals.

Key words

apocarotenoid - paracentrone - fucoxanthin - cross-coupling - C5 diene - allene

• References and Notes

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