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Synthesis 2020; 52(24): 3865-3873
DOI: 10.1055/s-0040-1707863
DOI: 10.1055/s-0040-1707863
special topic
Iridium(III)-Catalyzed Difluoroalkylation–Bicyclization of 1,7-Enynes toward Benzo[a]fluoren-5-ones under Visible-Light Photoredox Conditions
Authors
We are grateful for financial support from the National Natural Science Foundation of China (NSFC) (Grant No. 21971090).
Further Information
Publication History
Received: 05 April 2020
Accepted after revision: 07 May 2020
Publication Date:
16 June 2020 (online)
Published as part of the Special Topic Recent Advances in Metal-Catalyzed Ring Construction
Abstract
A new visible-light-induced Ir(III)-catalyzed difluoroalkylation–bicyclization of 1,7-enynes with ethyl 2-bromo-2,2-difluoroacetate (BrCF2CO2Et) is described, furnishing a wide range of difluoromethyl-containing benzo[a]fluoren-5-ones in good to excellent yields. The reaction is operationally simple, proceeds with high efficiency under mild conditions, and shows excellent functional group compatibility.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707863.
- Supporting Information (PDF)
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