Additions to Racemates: A Strategy for Developing Asymmetric Cross-Coupling Reactions

F. Wieland Goetzke; Stephen P. Fletcher

doi:10.1055/s-0040-1706033

Synlett, Table of Contents

Synlett 2021; 32(18): 1816-1825
DOI: 10.1055/s-0040-1706033

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Additions to Racemates: A Strategy for Developing Asymmetric Cross-Coupling Reactions

Authors

F. Wieland Goetzke
Stephen P. Fletcher∗

Abstract

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Abstract

In this Account, the authors describe their progress in developing catalytic asymmetric C(sp³)–C(sp³) and C(sp³)–C(sp²) cross-coupling reactions. Whereas most catalytic enantioselective transformations rely on prochiral or meso starting materials, strategies that use racemic starting materials are rare. Key features of these reactions are efficient mechanisms for deracemization. Here, the authors present copper-catalyzed alkylation and rhodium-catalyzed Suzuki–Miyaura-type arylation reactions, their underlying mechanisms, and their applications in complex-molecule syntheses.

Key words

asymmetric catalysis - arylboronic acids - copper catalysis - cross-coupling - rhodium catalysis - Suzuki–Miyaura reaction

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References

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