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Synthesis 2020; 52(05): 763-768
DOI: 10.1055/s-0039-1691528
DOI: 10.1055/s-0039-1691528
paper
Direct Oxidative Dearomatization of Indoles with Aromatic Ketones: Rapid Access to 2,2-Disubstituted Indolin-3-ones
This work was financially supported by the National Natural Science Foundation of China (No. 21801093) and the Natural Science Foundation of Shandong Province (Nos. ZR2017BB006, JQ201721).Further Information
Publication History
Received: 16 October 2019
Accepted after revision: 16 November 2019
Publication Date:
28 November 2019 (online)
§ These authors contributed equally to this work
Abstract
A metal-free oxidative dearomatization of indoles with aromatic ketones mediated by TEMPO oxoammonium salt is described. The dearomatization proceeds smoothly and displays a broad substrate scope with respect to both indoles and aromatic ketones in the presence of H2SO4, affording the corresponding 2,2-disubstituted indolin-3-ones in good yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1691528.
- Supporting Information
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