A Copper(I)-Mediated Tandem Three-Component Synthesis of 5-Allyl-1,2,3-triazoles

^‡ These authors contributed equally to this work.

Abstract

A copper(I)-mediated tandem three-component reaction using alkynes, azides, allyl iodides, CuI and NaNH₂ is developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further converted into 1,2,3-triazole-fused tricyclic scaffolds. This method features an efficient one-pot cascade route using commercial alkynes and affords the corresponding 5-allyl-1,2,3-triazoles with high yields and good selectivity under mild reaction conditions.

Key words

1,2,3-triazoles - multicomponent reactions - one-pot reactions - click reactions - copper catalyst

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