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Synthesis 2020; 52(14): 2121-2126
DOI: 10.1055/s-0039-1690883
DOI: 10.1055/s-0039-1690883
paper
α-Chymotrypsin-Induced Acetalization of Aldehydes and Ketones with Alcohols
National Natural Science Foundation of China (No. 21462001 and 11765002) and the Projects of Jiangxi Provincial Department of Science and Technology (No. 20181BBH80007 and 20192BBH80012).Further Information
Publication History
Received: 04 February 2020
Accepted after revision: 23 March 2020
Publication Date:
06 April 2020 (online)
Abstract
This is the first report of a simple and general method for acetalization of aldehydes via an α-chymotrypsin-induced reaction under mild conditions. A broad range of aromatic and heteroaromatic aldehydes have been acetalized under neutral conditions in good yields using a catalytic amount of chymotrypsin.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690883.
- Supporting Information
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