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Synthesis 2020; 52(08): 1253-1265
DOI: 10.1055/s-0039-1690219
DOI: 10.1055/s-0039-1690219
special topic
Palladium-Catalyzed [4+2] Annulation of Aryl and Alkenyl Carboxamides with 1,3-Dienes via C–H Functionalization: Synthesis of 3,4-Dihydroisoquinolones and 5,6-Dihydropyridinones
This work was supported by the Natural Science Foundation of Zhejiang Province (Grant No. LY18B020002) and the Nurturing Project, Taizhou University (Grant No. 2018PY049).Weitere Informationen
Publikationsverlauf
Received: 29. August 2019
Accepted after revision: 04. Oktober 2019
Publikationsdatum:
24. Oktober 2019 (online)
Published as part of the Special Topic Domino C–H Functionalization Reaction/Cascade Catalysis
Abstract
Palladium-catalyzed [4+2] annulation of aryl and alkenyl carboxamides with 1,3-dienes via C–H functionalization is developed using air as the terminal oxidant. The method demonstrates good functional group tolerance and high stereoselectivity, affording a series of 3,4-dihydroisoquinolones and 5,6-dihydropyridinones in yields of up to 99%.
Key words
palladium - [4+2] annulation - carboxamides - dienes - C–H functionalization - 3,4-dihydroisoquinolones - 5,6-dihydropyridinonesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690219.
- Supporting Information
- CIF File
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