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Synthesis 2019; 51(06): 1427-1434
DOI: 10.1055/s-0037-1611040
DOI: 10.1055/s-0037-1611040
paper
First Stereoselective Total Synthesis of Anti-Inflammatory Metabolite Penicillinolide A
Further Information
Publication History
Received: 21 August 2018
Accepted after revision: 27 September 2018
Publication Date:
14 November 2018 (online)
IICT/Pubs/2018/205
Abstract
The first asymmetric total synthesis of penicillinolide A is described. Key steps of the synthesis involve Jacobsen’s hydrolytic kinetic resolution (HKR), chelation controlled allylation, Brown’s asymmetric allylation, hydroboration, and Yamaguchi lactonization.
Key words
Jacobsen’s hydrolytic kinetic resolution (HKR) - chelation controlled allylation - Brown’s asymmetric allylation - hydroboration - Yamaguchi lactonizationSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611040.
- Supporting Information
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