Stereoselective Total Synthesis of (-)-Aspinolide B from (R)-2,3-O-Isopropylideneglyceraldehyde

Abstract

A stereoselective total synthesis of (-)-aspinolide B by a convergent strategy is reported.

Key words

(R)-2,3-O-isopropylideneglyceraldehyde - Jacobsen hydrolytic kinetic resolution - Sharpless asymmetric epoxidation - 1,2-anti selective reduction - Yamaguchi lactonization

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