Abstract
1,2-Dihaloalkenes readily undergo simultaneous or sequential difunctionalization through
transition-metal-catalyzed reactions, which makes them attractive building blocks
for complex unsaturated motifs. This review summarizes recent applications of such
transformations in C–C and C–heteroatom bond forming processes. The facile synthesis
of stereodefined alkene derivatives, as well as aromatic and heteroatomic compounds,
from 1,2-dihaloalkenes is thus outlined.
1 Introduction
2 Synthesis of 1,2-Dihaloalkenes
3 C–C Bond Forming Reactions
4 C–Heteroatom Bond Forming Reactions
5 Conclusion
Key words
1,2-dihaloalkenes - vinyl dihalides - transition-metal catalysis - cross-coupling
reactions - C–C bond formation - C–heteroatom bond formation
