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Synlett 2018; 29(11): 1505-1509
DOI: 10.1055/s-0037-1609751
DOI: 10.1055/s-0037-1609751
letter
Oxidative C–C Bond Cleavage for the Synthesis of Aryl Carboxylic Acids from Aryl Alkyl Ketones
This project was supported by the National Natural Science Foundation of China (21776260, 21773211 and 21376224), Natural Science Foundation of Zhejiang Province (LY17B060007) and Hangzhou Qianjiang Distinguished Experts Project.
Further Information
Publication History
Received: 05 March 2018
Accepted after revision: 11 April 2018
Publication Date:
16 May 2018 (online)
Abstract
A metal-free and one-pot two-step synthesis of aryl carboxylic acids from aryl alkyl ketones has been achieved. The reactions were performed with iodine as the catalyst, DMSO and TBHP as the oxidants. Under the optimal reaction conditions, a number of aryl alkyl ketones could be converted into their corresponding aryl carboxylic acids in good to excellent yields (up to 94%).
Key words
aryl alkyl ketones - aryl carboxylic acids - iodine - dimethyl sulfoxide - tert-butyl hydroperoxideSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609751.
- Supporting Information
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