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Synthesis 2018; 50(16): 3224-3230
DOI: 10.1055/s-0036-1591568
DOI: 10.1055/s-0036-1591568
special topic
Iodine-Mediated Intramolecular C–H Amination of Benzimidazoles: A Metal-Free Route to Dihydroimidazobenzimidazoles
We thank Science and Engineering Research Board (EMR-2015-43) and Council of Scientific and Industrial Research [02(0255)-2016-EMR-II] for the financial support. T.A.S. thanks Science and Engineering Research Board (PDF/2017/002653) for financial support.Further Information
Publication History
Received: 01 March 2018
Accepted after revision: 21 March 2018
Publication Date:
19 April 2018 (online)
Published as part of the Special Topic Modern Coupling Approaches and their Strategic Applications in Synthesis
Abstract
Iodine-mediated cyclization of benzimidazolylethylamines in the presence of base to give dihydroimidazobenzimidazoles via a dehydrogenative cross-coupling of C(sp2)–H and N–H bonds is reported. Metal-free conditions, preservation of the optical purity, and substrate scope are the important practical features.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591568. Included are HPLC chromatograms and NMR (1H and 13C) spectra.
- Supporting Information
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