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Synthesis 2018; 50(02): 349-360
DOI: 10.1055/s-0036-1591487
DOI: 10.1055/s-0036-1591487
paper
Catalyst-Free Regioselective Nazarov Cyclization of Aryl Allenyl Ketones
Authors
We are grateful to the National Natural Science Foundation of China (21302169), the Natural Science Foundation of Zhejiang Province (LQ16B020001), the Science Foundation of Zhejiang Sci-Tech University (13062121-Y), and the Program for Innovative Research Team of Zhejiang Sci-Tech University (13060052-Y) for financial support.
Further Information
Publication History
Received: 03 August 2017
Accepted after revision: 13 September 2017
Publication Date:
09 October 2017 (online)
Abstract
The catalyst-free Nazarov cyclization of aryl allenyl ketones under thermal condition is developed. Various densely functionalized 2,3-dihydroindanones or indenones are readily produced in moderate to excellent yields. Significantly, this procedure features high functional group tolerance and exclusive regioselectivity. The resulting substituted 2,3-dihydroindanones can be conveniently converted into valuable conjugated benzofulvene building blocks.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591487.
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