Synthesis of (±)-γ-Lycorane by Using an Intramolecular Friedel–Crafts Reaction

Abstract

A total synthesis of γ-lycorane has been achieved by employing N-tosylpyrrole as a key building block. The synthesis employs both an intermolecular and an intramolecular Friedel–Crafts reaction, as well as a completely diastereoselective hydrogenation of a late-stage pyrrole intermediate.

Key words

heterocycle - pyrrole - Friedel–Crafts - hydrogenation

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