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Synthesis 2017; 49(17): 3957-3961
DOI: 10.1055/s-0036-1589064
DOI: 10.1055/s-0036-1589064
special topic
A Simple Cobalt(II) Chloride Catalyzed N-Alkylation of Amines with Alcohols
Further Information
Publication History
Received: 12 April 2017
Accepted after revision: 30 May 2017
Publication Date:
11 July 2017 (online)
Dedicated to Professor David Milstein on the occasion of his 70th birthday
Published as part of the Special Topic Cobalt in Organic Synthesis
Abstract
A facile cobalt-catalyzed N-alkylation of amines with alcohols using inexpensive, commercially available CoCl2·6H2O is reported. Employing this readily available cobalt catalyst, a variety of amines with wide functional group tolerance were selectively alkylated under benign conditions.
Key words
cobalt catalysis - N-alkylation - amines - alcohols - hydrogen autotransfer - dehydrogenationSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1589064.
- Supporting Information
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