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Synthesis 2017; 49(16): 3692-3699
DOI: 10.1055/s-0036-1588780
DOI: 10.1055/s-0036-1588780
paper
Synthesis of 5-Arylpyrrole-2-carboxylic Acids as Key Intermediates for NBD Series HIV-1 Entry Inhibitors
Authors
Supported by: National Institutes of Health, USA (RO1 AI104416)
Further Information
Publication History
Received: 22 February 2017
Accepted after revision: 19 March 2017
Publication Date:
18 April 2017 (online)
Abstract
5-Arylpyrrole-2-carboxylic acids are important key intermediates in the synthesis of HIV-1 entry inhibitors (such as NBD-11021 and NBD-14010). Here we present a general method for the synthesis of some 5-arylpyrrole-2-carboxylic acids in three steps starting from pyrrole. By this method, the compounds could be prepared on gram scale and without chromatographic purification.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588780.
- Supporting Information (PDF)
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