Pattern-Generating Unimolecular Sensors: For Future Differential Sensing and Molecular Computing

Bhimsen Rout; Paul L. Bigliardi

doi:10.1055/s-0036-1588721

Synlett, Table of Contents

Synlett 2017; 28(09): 1005-1010
DOI: 10.1055/s-0036-1588721

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Pattern-Generating Unimolecular Sensors: For Future Differential Sensing and Molecular Computing

Bhimsen Rout*

^aInstitute of Medical Biology, Agency for Science, Technology and Research, 138648 Biopolis, Singapore

,

Paul L. Bigliardi

^aInstitute of Medical Biology, Agency for Science, Technology and Research, 138648 Biopolis, Singapore

^bYLL School of Medicine, National University of Singapore and UMC, National University Hospital, Singapore Email: bhimsen.rout@imb.a-star.edu.sg

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Abstract

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Abstract

Pattern-generating unimolecular sensors are an innovative class of analytical and computing systems that utilize inherent molecular mechanisms to create multiple optical responses in a manner similar to that in which arrays of small reporter molecules can be engineered to function as cross-reactive sensors. Pattern-generating unimolecular sensors can detect and discriminate between a wide range of chemical and biochemical analytes, and they can also be used in computation, where they function as molecular logic devices utilizing chemometric analysis. This feature article summarizes the various pattern-generating approaches and their miniaturization to a unimolecular level in the fields of differential sensing and molecular computing.

Key words

unimolecular sensors - pattern-based detection - nanodevice - molecular computing - molecular logic gates

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References

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