Synthesis of Tricyclic Isoxazoles via Sequential [3+2] Dipolar Cycloaddition­ and Palladium-Catalyzed Intramolecular Arylation Reactions

Abstract

An efficient synthetic route to tricyclic isoxazoles via sequential copper-catalyzed 1,3-dipolar cycloaddition and palladium-catalyzed intramolecular arylation of isoxazoles is described. Based on these reactions, a convenient one-pot synthesis of the tricyclic isoxazoles from terminal alkyne and hydroximoyl chlorides by using a cascade process was also developed.

Key words

isoxazoles - C–H activation - 1,3-dipolar cycloaddition - intramolecular arylation - tandem processes

• References

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