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Synlett 2017; 28(14): 1795-1800
DOI: 10.1055/s-0036-1588419
DOI: 10.1055/s-0036-1588419
letter
Metal-Free Mediated C-3 Methylsulfanylation of Imidazo[1,2-a]-pyridines with Dimethyl Sulfoxide as a Methylsulfanylating Agent
We thank the National Nature Science Foundation of China (Grant No. 21602202), the Science Foundation of Zhejiang Sci-Tech University (Grant Nos. 15062092-Y, 1206820-Y, and 1206821-Y), and the Zhejiang Provincial Top Key Academic Discipline of Chemical Engineering and Technology of Zhejiang Sci-Tech University for their financial support.
Weitere Informationen
Publikationsverlauf
Received: 01. März 2017
Accepted after revision: 18. April 2017
Publikationsdatum:
10. Mai 2017 (online)
Abstract
A simple approach is described for the regioselective C-3 methylsulfanylation of imidazo[1,2-a]pyridines through diiodine-mediated, acetone-promoted, C–S bond construction with dimethyl sulfoxide as both the source of the methylsulfanyl moiety and the solvent. Preliminary mechanistic investigations indicated that three different reaction mechanisms might be involved in the transformation.
Key words
methylsulfanylation - C–S bond formation - imidazopyridines - dimethyl sulfoxide - iodineSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588419.
- Supporting Information
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