One-Pot Synthesis of Imidazolyl Isoquinolines under a Palladium-Catalyzed C–H Activation/Annulation (CHAA) Reaction

Abstract

A microwave-assisted Pd-catalyzed one-pot C–H activation/annulation (CHAA) protocol has been developed for the synthesis of imidazo[2,1-a]isoquinolines and benzo[4,5]imidazo[2,1-a]isoquinolines. Further N-alkylation for the preparation of a series of the corresponding isoquinolium salts has also been demonstrated. The fluorescent properties of these isoquinolines have been studied.

Key words

C–H activation/annulation - microwave - fluorophore - heterocycle - fluorescent

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