Copper-Catalyzed Double C–N Bond Formation for the Synthesis of Diverse Benzimidazoles from N-Alkyl-2-iodoaniline and Sodium Azide

Abstract

An efficient approach to the synthesis of benzimidazole derivatives has been achieved by copper-catalyzed double C–N bonds formation of N-alkyl-2-iodoaniline and sodium azide. The reaction was supposed to proceed through copper-catalyzed tandem reaction of S_NAr reaction, aerobic oxidation of C(sp³)–H bond and intramolecular C–N bond formation sequence. Structurally diverse 2-aryl, alkenyl and alkyl benzoimidazole derivatives were assembled by this methodology.

Key words

copper catalyst - C–N bond formation - benzimidazoles - tandem reaction - N-heterocyclic compounds

• References and Notes

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