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DOI: 10.1055/s-0035-1562519
Solid-Phase Synthesis of Heterocycles with α-Haloketones as the Key Building Blocks
Publication History
Received: 31 May 2016
Accepted after revision: 18 June 2016
Publication Date:
11 August 2016 (online)
Abstract
This short review summarizes the use of α-haloketones in the preparation of various heterocycles with the application of solid-phase synthesis. A literature survey revealed that eighteen different five-to-seven membered scaffolds are accessible, including condensed heterocycles and bisheterocycles.
1 Introduction
2 Thiazoles: Path A
3 Thiazolo[2,3-b]quinazolines: Path A
4 Dihydroimidazo[2,1-b]thiazoles: Path A
5 Imidazo[1,2-a]pyrimidines: Path A
6 Benzodiazepinones: Path A
7 Benzothiadiazepine 1,1-Dioxides: Path A/B
8 Benzothiazine 1,1-Dioxides: Path B
9 Morpholines: Path B
10 Imidazoles: Path B
11 Thiophenes: Path A
12 Thiophenes: Path B
13 Pyridazinones: Path A
14 Pyrroles: Path A
15 Pyrroles: Path B
16 Piperazines: Path A
17 Oxazoles: Path B
18 Quinolines: Path B
19 Indazoles: Path C
20 Quinazolines: Path C
21 Indoles: Path C
22 Conclusion
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