Reductive Cyclization of 1,6- and 1,7-Enynes Catalyzed by Iron Complexes

Tuo Xi; Xu Chen; Heyi Zhang; Zhan Lu

doi:10.1055/s-0035-1561957

Synthesis, Inhaltsverzeichnis

Synthesis 2016; 48(17): 2837-2844
DOI: 10.1055/s-0035-1561957

special topic

Reductive Cyclization of 1,6- and 1,7-Enynes Catalyzed by Iron Complexes

Tuo Xi

Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. of China eMail: luzhan@zju.edu.cn

,

Xu Chen

Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. of China eMail: luzhan@zju.edu.cn

,

Heyi Zhang

Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. of China eMail: luzhan@zju.edu.cn

,

Zhan Lu*

Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. of China eMail: luzhan@zju.edu.cn

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Abstract

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Abstract

Iron-catalyzed reductive cyclization of 1,6- and 1,7-enynes was demonstrated by using an oxazoline iminopyridine ligand. Alcohol, ketone, ester, ether, halide, amine, amide, imine, nitrile, silyl, and alkyne groups are tolerated under the mild reaction conditions. A speculative mechanism is proposed on the basis of deuteration studies. A primary enantioselective transformation was also conducted.

Key words

iron - catalysis - enynes - cyclizations - asymmetric synthesis

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Referenzen

References

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