Abstract
Bicyclo[3.3.0]octan-1-ol (diquinane ring system), bicyclo[4.3.0]nonan-1-ol (hydrindane
ring system), and bicyclo[4.4.0]decan-1-ol (decalin ring system) belong to the medium-sized
rings family which represent important scaffolds of numerous natural products. Thus,
the development of new routes leading to such scaffolds is of importance because such
carbocycles are ubiquitous in numerous biologically active compounds. This short review
will focus on the main approaches reported since 2000, leading to these bicyclic scaffolds
with high diastereo- and/or enantioselectivities.
1 Introduction
2 Diastereoselective Approaches
3 Diastereo- and Enantioselective Catalytic Approaches
4 Conclusion
Key words
bicyclo[n.m.0]alkan-1-ol - cyclization - diastereoselectivity - enantioselectivity
- metal catalysis
