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Synthesis 2016; 48(22): 3941-3950
DOI: 10.1055/s-0035-1561481
DOI: 10.1055/s-0035-1561481
paper
Modular Synthesis of Quinazolinone-Fused Phenanthridinones by a Palladium-Catalyzed Cascade C–H/N–H Arylation Process
Further Information
Publication History
Received: 02 March 2016
Accepted after revision: 16 May 2016
Publication Date:
07 July 2016 (online)
Abstract
An efficient palladium-catalyzed protocol for the tandem synthesis of quinazolinone-fused phenanthridinones from 2-arylquinazolinones and o-dihaloarenes is described. This reaction sequence comprises direct intermolecular C–H arylation of 2-arylquinazolinones followed by an intramolecular aryl amidation reaction, affording 14H-quinazolino[3,2-f]phenanthridin-14-one derivatives in moderate to good yields.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561481.
- Supporting Information
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For recent reviews, see:
Selected reviews on chelation-assisted Pd-catalyzed C–H functionalizations: