A New Simplified Protocol for Copper(I) Alkyne–Azide Cycloaddition Reactions Using Low Substoichiometric Amounts of Copper(II) Precatalysts in Methanol

Dedicated to Professor Steven V. Ley FRS for his excellent achievements in organic chemistry on the occasion of his 70^th birthday

Abstract

Copper(II) carboxylates are reduced efficiently by methanol in the presence of alkynes and form yellow alkynylcopper(I) polymeric precatalysts that are involved with azides, in the absence of added ligands, in the catalytic cycles that result in the formation of 1,4-disubstituted 1,2,3-triazoles.

Key words

alkyne - azide - copper(I) - cycloaddition - triazole

• References

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