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Synthesis 2016; 48(01): 122-130
DOI: 10.1055/s-0035-1560508
DOI: 10.1055/s-0035-1560508
paper
Catalyst-Free Regioselective C-3 Nitrosation of Imidazopyridines with tert-Butyl Nitrite under Neutral Conditions
Further Information
Publication History
Received: 05 August 2015
Accepted after revision: 25 September 2015
Publication Date:
30 October 2015 (online)
Abstract
We have successfully developed a novel and efficient catalyst-free method for the synthesis of 3-nitroso-substituted imidazopyridines, from readily available imidazo[1,2-a]pyridines and tert-butyl nitrite, in good to excellent yields. Importantly, the use of transition-metal catalysts, stoichiometric amounts of acids, and toxic or potentially dangerous oxidants is avoided. This easy and practical method complements nitrosation reactions by expanding the scope and practicality, and should attract much attention in synthetic and pharmaceutical chemistry.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560508.
- Supporting Information
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For selected examples, see:
For selected examples, see :