We have demonstrated a facile synthesis of diversely substituted quinazolines and
3,4-dihydroquinazolines through the o-iodoxybenzoic acid (IBX) mediated tandem reaction of readily available o-aminobenzylamine and aldehydes. The yield of the reactions generally ranged from
70% to 95%. This mild protocol provides an efficient strategy toward the synthesis
of these classes of heterocycles.
Key words
quinazolines - dihydroquinazolines -
o-iodoxybenzoic acid -
o-aminobenzylamine - aldehydes