Synthesis of (R)-Lactic Acid and (2R,5R)-2-tert-Butyl-5-methyl-1,3-dioxolan-4-one

Abstract

A convenient procedure for the synthesis of very expensive (R)-lactic acid from relatively inexpensive (R)-alanine is described. Its subsequent conversion into a chiral dioxolanone can be carried out by using an inexpensive pivalaldehyde–tert-butanol mixture.

Key words

chiral pool - stereoselective synthesis - (R)-lactic acid - (R)-alanine - diazotization - 1,3-dioxolan-4-one

• References

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