Synthesis 2015; 47(10): 1387-1389
DOI: 10.1055/s-0034-1380505
psp
© Georg Thieme Verlag Stuttgart · New York

A New and Practical Synthesis of Vortioxetine Hydrobromide

Yongjun Mao
,
Luobin Jiang
,
Tianyun Chen
,
Haijun He
,
Gang Liu
,
Han Wang*
Further Information

Publication History

Received: 25 January 2015

Accepted after revision: 05 March 2015

Publication Date:
13 April 2015 (online)


Abstract

A new and improved synthetic route to vortioxetine hydrobromide is established on a hectogram scale through three simple steps in 63% yield and with 99% purity (HPLC). The key step is the cyclization of the piperazine ring in the final step. Purification methods for the intermediates involved in the route are given.

 
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