Bis(indolyl)methane Alkaloids: Isolation, Bioactivity, and Syntheses

P. J. Praveen; P. S. Parameswaran; M. S. Majik

doi:10.1055/s-0034-1380415

Synthesis, Table of Contents

Synthesis 2015; 47(13): 1827-1837
DOI: 10.1055/s-0034-1380415

short review

Bis(indolyl)methane Alkaloids: Isolation, Bioactivity, and Syntheses

P. J. Praveen

^aCSIR-National Institute of Oceanography, Bioorganic Chemistry Laboratory, Dona Paula, Goa 403 004, India

^bCSIR-National Institute of Oceanography Regional Centre, Kochi 682 018, India Email: param@nio.org

,

P. S. Parameswaran*

^bCSIR-National Institute of Oceanography Regional Centre, Kochi 682 018, India Email: param@nio.org

,

M. S. Majik*

^cDepartment of Chemistry, Goa University, Goa 403 206, India Email: majikms@gmail.com

› Author Affiliations

Abstract

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Abstract

Bis(indolyl)methane (BIM) alkaloids are an important group of bioactive natural products predominantly found in marine organisms. Thus, compounds like arsindoline A and B, vibrindole A, arundine, and trisindoline are found in marine bacteria, while the related compound, streptindole is obtained from Streptococcus faecium IB 37, found in human feces. In recent years, these molecules, which display a wide range of biological properties (antibacterial, antiviral, anti-oxidant, neurotoxic activity etc.), have attracted the attention of several synthetic and natural product chemists. This review lists selected bis(indolyl)methane analogues reported from different natural sources to date, together with their biological properties and synthesis.

1 Introduction

2 Occurrence, Isolation, Structure Elucidation, and Biological Activity

3 Synthetic Approaches towards Bis(indolyl)methanes

4 Conclusions

Key words

bis(indolyl)methanes - natural products - isolation - synthesis - bioactive metabolites

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References

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