Synlett 2015; 26(08): 1093-1095
DOI: 10.1055/s-0034-1380409
letter
© Georg Thieme Verlag Stuttgart · New York

Brønsted Acid Catalyzed Asymmetric Silylation of Alcohols

Kengo Hyodo
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany   Email: list@kofo.mpg.de
,
Shikha Gandhi
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany   Email: list@kofo.mpg.de
,
Manuel van Gemmeren
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany   Email: list@kofo.mpg.de
,
Benjamin List*
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany   Email: list@kofo.mpg.de
› Author Affiliations
Further Information

Publication History

Received: 10 January 2015

Accepted after revision: 31 January 2015

Publication Date:
24 February 2015 (online)

 


Abstract

We report a catalytic enantioselective desymmetrization of meso-1,2-diols by monosilylation using a chiral enantiopure Brønsted acid as catalyst and hexamethyldisilazane (HMDS) as silyl source.


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The silylation of alcohols is a widespread transformation in organic synthesis, typically used to introduce protecting groups. Frequently employed protocols involve basic conditions and a silyl chloride or triflate reagent.[1] Recently, the first examples of catalytic asymmetric alcohol silylations have been described.[2] Interestingly, these methods are based on electrophilic silicon reagents employed under basic conditions. We were intrigued to design catalytic cycles that are based on an acidic activation of basic silicon sources, which are susceptible to proto desilylation. Here we report our studies on the Brønsted acid catalyzed desymmetrization of meso-diols using hexamethyldi­silazane (HMDS) as the silicon source and the chiral spirocyclic phosphoric acid STRIP, recently introduced from this laboratory, as the catalyst.

The enantioselective desymmetrization of meso-diols is one of the most prominent strategies to access the corresponding monoprotected derivatives in their enantiopure form. This reaction is commonly realized by stereoselective acyl transfer reactions.[3] However, the introduced acyl group may not always be suited as a protecting group in a given synthetic context, thus rendering further functional group transformations necessary.[2a] As an alternative, highly efficient catalytic enantioselective monosilylations of meso-­diols have been developed by Hoveyda, Snapper and co-workers.[2a] [b] [c] In analogy to the most common protocols for the silyl protection of alcohols, which are typically carried out under basic conditions,[1] these reactions involve the use of an enantiopure basic catalyst in combination with an achiral stoichiometric base such as Hünig’s base. Despite the predominance of basic conditions for the silyl protection of alcohols, non-enantioselective protocols using acid catalysts in combination with basic silyl transfer reagents have also been developed.[1] [4]

Based on the mechanism of this type of transformation, we hypothesized that it should be possible to render the overall process enantioselective by utilizing a chiral enantiopure Brønsted acid catalyst (Scheme [1]).[5] Accordingly, protonation of the basic silicon source should generate an ion pair consisting of a cationic silylium source accompanied by the enantiopure counteranion.

Zoom Image
Scheme 1 Design of a Brønsted acid catalyzed desymmetrization of meso-diols

The reaction of this ion pair intermediate with the diol substrate could then potentially proceed enantioselectively via a desymmetrization reaction.

Table 1 Identification of a Suitable Silylating Agent and Catalyst

Entry

Nu-SiR3

Equiv

Conv. (%)a

erb

 1

TMSCl
2a

1.2

 0

-

 2

2b

1.2

 0

-

 3

2c

1.2

20

63:37

 4

TMSCN
2d

1.2

11

63:37

 5

2e

0.6

42

38.5:61.5

 6

2f

1.2

 8

50:50

 7

2g

0.6

78

81.5:18.5

 8

2h

0.6

60

78:22

 9

2i

0.6

 0

-

10

2j

0.6

21

81:19

11c

2g

0.6

83

94:6

a Determined by 1H NMR using 1,1,2,2-tetrachloroethane as an internal standard.

b Determined by HPLC on a chiral stationary phase.

c (S)-STRIP (5; see Table [2]) was used as catalyst.

We began by studying several prospective silyl transfer reagents utilizing TRIP (4a)[6] as reference catalyst (Table [1]). Comparably non-basic silylating agents trimethylsilyl chloride (2a) and allyltrimethylsilane (2b) proved to be inefficient for product formation under the reaction conditions tested (entries 1 and 2 in Table [1]). However, switching to more basic silyl transfer reagents enabled reactivity with moderate to good conversion, albeit with limited stereoinduction (entries 3–6 in Table [1]). Further screening revealed HMDS (2g) and its derivatives as the most promising reagents (entries 7–10 in Table [1]). We thus continued our studies with the commercially available and inexpensive HMDS as silyl source and further optimized the reaction conditions.[7] Through these studies we identified catalyst 5 (STRIP) as best catalyst for this transformation,[6c] giving good conversion and stereoinduction in our model reaction (83% conversion and 94:6 er, entry 11 in Table [1]).

Table 2 Substrate Scope of the STRIP-Catalyzed Desymmetrization of meso-Diols

Entry

R

Product

Time (d)

Yield (%)

era

 1

Ph

3a

 3

84

95:5

 2b

4-MeC6H4

3b

 2

96

95:5

 3

3-MeC6H4

3c

 7

92

93.5:6.5

 4

2-MeC6H4

3d

 7

91

90:10

 5b

4-i-PrC6H4

3e

 1

99

92.5:7.5

 6c–e

4-FC6H4

3f

10

77

95: 5

 7

4-ClC6H4

3g

 1

87

95.5:4.5

 8e

2-ClC6H4

3h

 5

94

89:11

 9

4-BrC6H4

3i

 6

76

90.5:9.5

10

-(CH2)4-

3j

 7

99f

75.5:24.5g

a Determined by HPLC on a chiral stationary phase.

b Reaction was conducted at 40 °C

c Carbon tetrachloride was used as solvent instead of cyclohexane.

d Amount of catalyst 5 used was 10 mol%.

e Compound 2h was used as a silylating reagent instead of 2g.

f Conversion determined by 1H NMR using 1,1,2,2-tetrachloroethane as an internal standard.

g Determined by GC on a chiral stationary phase.

With optimal reaction conditions in hand, we continued to study the scope of the Brønsted acid catalyzed desymmetrization of meso-diols (Table [2]). The reaction turned out to be tolerant of both electron-rich (entries 1–5 in Table [2]) as well as electron-poor (entries 6–9 in Table [2]) aromatic substituents, giving moderate to good yields (76–99%) and enantioselectivities (89:11 to 95.5:4.5 er) in all cases.[8] When studying the effects of regioisomerism, we found that para-substitution led to superior results as compared to both meta- and ortho-substitution (entries 2–4 in Table [2]). ­Aliphatic substrates, as exemplified by cis-1,2-cyclohexanediol, showed good reactivity, albeit with reduced stereo­induction (entry 10 in Table [2]).

In summary, we have developed a catalytic asymmetric desymmetrization of meso-1,2-diols by monosilylation. Our method employs STRIP (5) as enantioselective catalyst, together with HMDS (2g) as silyl source. Moderate to good results were obtained with a number of aryl-substituted meso-diols. Further studies on the use of this type of ­Brønsted acid catalyzed enantioselective silylation are currently ongoing in our laboratories.


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Acknowledgment

Generous support from the Max-Planck-Society, the European Research Council (Advanced grant ‘High Performance Lewis Acid Organocatalysis, HIPOCAT’), the Naito Foundation (fellowship to K.H.), and the Alexander von Humboldt Foundation (fellowship to S.G.) is gratefully acknowledged.

Supporting Information

  • References and Notes

  • 1 Greene TW, Wuts PG. M. Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols. In Protective Groups in Organic Synthesis . John Wiley & Sons; New York: 1999. 3rd ed., 17-245
    • 2a Zhao Y, Rodrigo J, Hoveyda AH, Snapper ML. Nature (London) 2006; 443: 67
    • 2b Zhao Y, Mitra AW, Hoveyda AH, Snapper ML. Angew. Chem. 2007; 119: 8623
    • 2c Manville N, Alite H, Haeffner F, Hoveyda AH, Snapper ML. Nature Chem. 2013; 5: 768
    • 2d Sheppard CI, Taylor JL, Wiskur SL. Org. Lett. 2011; 13: 3794
    • 2e Weickgenannt A, Mewald M, Oestreich M. Org. Biomol. Chem. 2010; 8: 1497

    • For selected examples of non-catalytic asymmetric silylations, see:
    • 2f Isobe T, Fukuda K, Araki Y, Ishikawa T. Chem. Commun. 2001; 243
    • 2g Rendler S, Auer G, Oestreich M. Angew. Chem. Int. Ed. 2005; 44: 7620
    • 3a García-Urdiales E, Alfonso I, Gotor V. Chem. Rev. 2004; 105: 313
    • 3b Enriquez-Garcia A, Kundig EP. Chem. Soc. Rev. 2012; 41: 7803
    • 3c Müller CE, Schreiner PR. Angew. Chem. Int. Ed. 2011; 50: 6012
    • 4a Morita T, Okamoto Y, Sakurai H. Tetrahedron Lett. 1980; 21: 835
    • 4b Olah GA, Husain A, Gupta BG. B, Salem GF, Narang SC. J. Org. Chem. 1981; 46: 5212
    • 4c Veysoglu T, Mitscher LA. Tetrahedron Lett. 1981; 22: 1299
    • 4d Bruynes CA, Jurriens TK. J. Org. Chem. 1982; 47: 3966
    • 4e Suzuki T, Watahiki T, Oriyama T. Tetrahedron Lett. 2000; 41: 8903
    • 4f Firouzabadi H, Iranpoor N, Amani K, Nowrouzi F. J. Chem. Soc., Perkin Trans. 1 2002; 2601
    • 4g Shaterian HR, Shahrekipoor F, Ghashang M. J. Mol. Catal. A.: Chem. 2007; 272: 142
    • 5a Mahlau M, List B. Isr. J. Chem. 2012; 52: 630
    • 5b Phipps RJ, Hamilton GL, Toste FD. Nature Chem. 2012; 4: 603
    • 5c Mahlau M, List B. Angew. Chem. Int. Ed. 2013; 52: 518
    • 5d Akiyama T. Chem. Rev. 2007; 107: 5744
    • 5e Kampen D, Reisinger CM, List B. Chiral Brønsted Acids for Asymmetric Organocatalysis. In Asymmetric Organocatalysis . Vol. 291. List B. Springer; Berlin/Heidelberg: 2009: 1-37
    • 6a Adair G, Mukherjee S, List B. Aldrichimica Acta 2008; 41: 31
    • 6b Klussmann M, Ratjen L, Hoffmann S, Wakchaure V, Goddard R, List B. Synlett 2010; 2189
    • 6c For the first report of STRIP, see: Čorić I, Müller S, List B. J. Am. Chem. Soc. 2010; 132: 17370
  • 7 For further screening of reaction conditions and catalysts, see the Supporting Information.
  • 8 The following procedure is representative: To a solution of catalyst 5 (3.6 mg, 5.00 μmol) in cyclohexane (1.0 mL) HMDS (2g, 12.5 μL, 0.0600 mmol) was added at r.t. and the resulting mixture was stirred for 2 h, after which, meso-diol 1a (21.4 mg, 0.100 mmol) was added. The reaction was judged to be complete when the reaction mixture turned into a clear, homogeneous solution. The solvent was removed by evaporation and the crude mixture was purified by silica gel column chromatography (hexane–EtOAc, 95:5), giving 3a (24.0 mg, 84%) as a colorless solid. 1H NMR (500 MHz, CD2Cl2): δ = 7.22–7.30 (m, 10 H), 4.74 (d, J = 5.0 Hz, 1 H), 4.71 (d, J = 5.0 Hz, 1 H), 2.39 (br, 1 H), –0.09 (s, 9 H). 13C NMR (125 MHz, CD2Cl2): δ = 141.6, 141.5, 128.3, 128.2, 128.1, 128.0, 127.9, 127.7, 79.6, 78.9, 0.00. HRMS (ESI, +ve): m/z [M + Na] calcd for C17H22NaO2Si: 309.1287; found: 309.1281. HPLC (Chiralcel OJ-H, heptane–i-PrOH = 95:5, flow rate = 0.5 mL/min, λ = 206 nm): t R (major) = 12.6 min, t R (minor) = 16.1 min.

  • References and Notes

  • 1 Greene TW, Wuts PG. M. Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols. In Protective Groups in Organic Synthesis . John Wiley & Sons; New York: 1999. 3rd ed., 17-245
    • 2a Zhao Y, Rodrigo J, Hoveyda AH, Snapper ML. Nature (London) 2006; 443: 67
    • 2b Zhao Y, Mitra AW, Hoveyda AH, Snapper ML. Angew. Chem. 2007; 119: 8623
    • 2c Manville N, Alite H, Haeffner F, Hoveyda AH, Snapper ML. Nature Chem. 2013; 5: 768
    • 2d Sheppard CI, Taylor JL, Wiskur SL. Org. Lett. 2011; 13: 3794
    • 2e Weickgenannt A, Mewald M, Oestreich M. Org. Biomol. Chem. 2010; 8: 1497

    • For selected examples of non-catalytic asymmetric silylations, see:
    • 2f Isobe T, Fukuda K, Araki Y, Ishikawa T. Chem. Commun. 2001; 243
    • 2g Rendler S, Auer G, Oestreich M. Angew. Chem. Int. Ed. 2005; 44: 7620
    • 3a García-Urdiales E, Alfonso I, Gotor V. Chem. Rev. 2004; 105: 313
    • 3b Enriquez-Garcia A, Kundig EP. Chem. Soc. Rev. 2012; 41: 7803
    • 3c Müller CE, Schreiner PR. Angew. Chem. Int. Ed. 2011; 50: 6012
    • 4a Morita T, Okamoto Y, Sakurai H. Tetrahedron Lett. 1980; 21: 835
    • 4b Olah GA, Husain A, Gupta BG. B, Salem GF, Narang SC. J. Org. Chem. 1981; 46: 5212
    • 4c Veysoglu T, Mitscher LA. Tetrahedron Lett. 1981; 22: 1299
    • 4d Bruynes CA, Jurriens TK. J. Org. Chem. 1982; 47: 3966
    • 4e Suzuki T, Watahiki T, Oriyama T. Tetrahedron Lett. 2000; 41: 8903
    • 4f Firouzabadi H, Iranpoor N, Amani K, Nowrouzi F. J. Chem. Soc., Perkin Trans. 1 2002; 2601
    • 4g Shaterian HR, Shahrekipoor F, Ghashang M. J. Mol. Catal. A.: Chem. 2007; 272: 142
    • 5a Mahlau M, List B. Isr. J. Chem. 2012; 52: 630
    • 5b Phipps RJ, Hamilton GL, Toste FD. Nature Chem. 2012; 4: 603
    • 5c Mahlau M, List B. Angew. Chem. Int. Ed. 2013; 52: 518
    • 5d Akiyama T. Chem. Rev. 2007; 107: 5744
    • 5e Kampen D, Reisinger CM, List B. Chiral Brønsted Acids for Asymmetric Organocatalysis. In Asymmetric Organocatalysis . Vol. 291. List B. Springer; Berlin/Heidelberg: 2009: 1-37
    • 6a Adair G, Mukherjee S, List B. Aldrichimica Acta 2008; 41: 31
    • 6b Klussmann M, Ratjen L, Hoffmann S, Wakchaure V, Goddard R, List B. Synlett 2010; 2189
    • 6c For the first report of STRIP, see: Čorić I, Müller S, List B. J. Am. Chem. Soc. 2010; 132: 17370
  • 7 For further screening of reaction conditions and catalysts, see the Supporting Information.
  • 8 The following procedure is representative: To a solution of catalyst 5 (3.6 mg, 5.00 μmol) in cyclohexane (1.0 mL) HMDS (2g, 12.5 μL, 0.0600 mmol) was added at r.t. and the resulting mixture was stirred for 2 h, after which, meso-diol 1a (21.4 mg, 0.100 mmol) was added. The reaction was judged to be complete when the reaction mixture turned into a clear, homogeneous solution. The solvent was removed by evaporation and the crude mixture was purified by silica gel column chromatography (hexane–EtOAc, 95:5), giving 3a (24.0 mg, 84%) as a colorless solid. 1H NMR (500 MHz, CD2Cl2): δ = 7.22–7.30 (m, 10 H), 4.74 (d, J = 5.0 Hz, 1 H), 4.71 (d, J = 5.0 Hz, 1 H), 2.39 (br, 1 H), –0.09 (s, 9 H). 13C NMR (125 MHz, CD2Cl2): δ = 141.6, 141.5, 128.3, 128.2, 128.1, 128.0, 127.9, 127.7, 79.6, 78.9, 0.00. HRMS (ESI, +ve): m/z [M + Na] calcd for C17H22NaO2Si: 309.1287; found: 309.1281. HPLC (Chiralcel OJ-H, heptane–i-PrOH = 95:5, flow rate = 0.5 mL/min, λ = 206 nm): t R (major) = 12.6 min, t R (minor) = 16.1 min.

Zoom Image
Scheme 1 Design of a Brønsted acid catalyzed desymmetrization of meso-diols