Generation of Indene Derivatives by Tandem Reactions

Guanyinsheng Qiu; Jie Wu

doi:10.1055/s-0034-1379318

Synlett, Inhaltsverzeichnis

Synlett 2014; 25(19): 2703-2713
DOI: 10.1055/s-0034-1379318

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Generation of Indene Derivatives by Tandem Reactions

Guanyinsheng Qiu

^aCollege of Biological, Chemical Science and Engineering, Jiaxing University, 118 Jiahang Road, Jiaxing 314001, P. R. of China

,

Jie Wu*

^bDepartment of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, P. R. of China Fax: +86(21)65641740 eMail: jie_wu@fudan.edu.cn

^cState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. of China

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Abstract

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Abstract

As a privileged motif, the indene core can be found in many natural products and pharmaceuticals. Our continued interest in the construction of natural product like compounds prompted us to develop efficient and mild protocols for the generation of indene derivatives. This account describes two typical procedures that involve tandem reactions: a base-mediated cyclization of 1-alkenyl-2-arylalkynes and a palladium-catalyzed annulation of 1-alkynyl-2-halobenzenes. Diversity and complexity can be easily incorporated during these reaction processes.

1 Introduction

2 Synthesis of Indene Derivatives by Base-Promoted Cyclization of (2-Alkenylphenyl)alkynes

3 Formation of Indenes by Palladium-Catalyzed Reactions of gem-Dibromoolefins

4 Palladium-Catalyzed Reactions of 1-Alkynyl-2-bromobenzenes

5 Outlook and Conclusion

Key words

indenes - catalysis - palladium - tandem reaction - cyclization

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Referenzen

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