Bromotriphenylphosphonium Salt Promoted One-Pot Cyclization to 2-Fluoroalkyl-Substituted Indoles

Abstract

2-Fluoroalkyl-substituted indoles were prepared in moderate to excellent yields through bromotriphenylphosphonium salt promoted ring formation with fluorine-containing carboxylic acids in the presence of triethylamine in toluene at reflux temperature. A range of 2-fluoroalkyl-substituted indole derivatives can be conveniently prepared.

Key words

cyclization - fluoroalkyl - indole - one-pot reaction - ylides

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