Synthesis of Carbalexin B, Clausine A, Clauszoline M, and 2,8-Dihydroxy-3-methylcarbazole

Konstanze K. Julich-Gruner; Arndt W. Schmidt; Hans-Joachim Knölker

doi:10.1055/s-0034-1378383

Synthesis, Inhaltsverzeichnis

Synthesis 2014; 46(19): 2651-2655
DOI: 10.1055/s-0034-1378383

paper

Synthesis of Carbalexin B, Clausine A, Clauszoline M, and 2,8-Dihydroxy-3-methylcarbazole

Konstanze K. Julich-Gruner

Department of Chemistry, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany Fax: +49(351)46337030 eMail: hans-joachim.knoelker@tu-dresden.de

,

Arndt W. Schmidt

Department of Chemistry, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany Fax: +49(351)46337030 eMail: hans-joachim.knoelker@tu-dresden.de

,

Hans-Joachim Knölker*

Department of Chemistry, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany Fax: +49(351)46337030 eMail: hans-joachim.knoelker@tu-dresden.de

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Abstract

Using a palladium(II)-catalyzed oxidative cyclization of an N,N-diarylamine, we have achieved the total synthesis of the 2,8-dioxygenated carbazole alkaloids carbalexin B, clausine A, clauszoline M, and 2,8-dihydroxy-3-methylcarbazole.

Key words

alkaloids - catalysis - cyclization - natural products - palladium

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Referenzen

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