Enantioselective Organocatalytic Michael Addition of Cyclopentane-1,2-diones to Nitroolefins

Abstract

Organocatalytic Michael additions of cyclopentane-1,2-dione to different nitroolefins have been investigated. Cyclopentane-1,2-dione undergoes an organocatalytic reaction with substituted nitroolefins giving 3-substituted products in good to high yields (48–97%) and good stereoselectivity (up to 76% ee).

Key words

Michael addition - asymmetric synthesis - asymmetric catalysis - enantioselectivity - electrophilic addition - ketones

• References


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